Figure 6.
Figure 6. Superposition of mutant TK[HSV1](Q125N) in complex
with dT (thick solid lines, C atoms
marked by small dots, hydrogen bonds are dotted) with wild-type
TK[HSV1] in complex with aciclovir (thin solid lines),[19]
ganciclovir (thin dotted lines)[19]and dT (thick dotted
lines).[19] For sake of clarity, side chains are only drawn for
TK[HSV1](Q125N):dT and TK[HSV1]:aciclovir. Water molecules and
hydrogen bonds are depicted for TK[HSV1](Q125N):dT (black
circles) and TK[HSV1]:aciclovir (pale circles). For aciclovir,
only the location of the hydroxyl group at the 5 -OH
position of dT is shown.
atoms
marked by small dots, hydrogen bonds are dotted) with wild-type
TK[HSV1] in complex with aciclovir (thin solid lines),[19]
ganciclovir (thin dotted lines)[19]and dT (thick dotted
lines).[19] For sake of clarity, side chains are only drawn for
TK[HSV1](Q125N):dT and TK[HSV1]:aciclovir. Water molecules and
hydrogen bonds are depicted for TK[HSV1](Q125N):dT (black
circles) and TK[HSV1]:aciclovir (pale circles). For aciclovir,
only the location of the hydroxyl group at the 5 
-OH
position of dT is shown.