Figure 5 - full size

Figure 5.
Moderately selective compound 16 binds to mouse iNOSox similarly to bulky quinazoline and aminopyridine inhibitors and induces the Gln-open conformation. Residues are colored according to Figure 2. The F[o] – F[c] electron density map contoured at 3 (blue mesh) is shown around the inhibitor (pink).