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Figure 5.
Fig. 5. The model of membrane-embedded GlpG. (a) The C^α
trace of the protein is shown in yellow, externally bound water
in red, and water inside the membrane protein in blue. The water
molecules substituting for Trp136 in the mutant are shown in
white. The two horizontal lines mark the boundaries of the
hydrophobic core of the membrane around the protease. (b) A
histogram of the number of water molecules observed across the
bilayer in the same color scheme as in (a). (c) The location of
various structural elements important for protease function
within the lipid bilayer. Parts of L1 (marked by *) and TM helix
S2 (**) are omitted to show the internal active site.
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