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Figure 5.
Figure 5. (a) FK506 (from PDB 1FKF) modeled in the
ligand-binding pocket of wild-type (violet) and E60Q (cyan)
FKBP12. The rotation of W59 leads to a conformation that creates
steric clash between its side chain and the docked FK506. (b)
The network of interacting amino acids and Wat3 in FKBP12.
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