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Figure 5.
Figure 5. Overview of the Putative Actin-Binding Site
(A) Surface model of the complex of Plasmodium profilin (green)
with actin (gray). Note the unique β-hairpin domain reaching
upward toward actin on the right. The proline-rich peptide is
shown in orange.
(B–D) Details of the three most
important sites contributing to the profilin-actin interaction,
as discussed in the text. Human profilin 1 and actin (Ferron et
al., 2007) are shown in pink and gray, respectively. The
Plasmodium profilin crystal structure superimposed with the
human profilin 1 from the complex is shown in green.
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