|
Figure 5.
Figure 5. Surface representation of the endoNF homotrimer in
complex with sialic acid. The molecular surface of the left
trimer is colored by electrostatic potential (blue, positive;
red, negative),whereas the transparent surface of the right
trimer shows the underlying ribbon model. Sialic acid residues
bound to the  -barrel
as  2,8-linked
dimer and as monomer to the -prism
domain of the spike are green spheres. Polymeric sialic acid
could simultaneously interact with both binding sites, on the
spike (yellow monomer) and the -barrel
(red monomer) and be cleaved by the active site of the third
subunit (blue monomer).
|
