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Figure 5.
FIG. 5. Stereo representations of C  traces of AT colored
according to root mean squared deviation from native AT. a,
the C trace of the P13 Ala
(ball) variant reveals surprisingly profound main chain
differences when compared with the -glycoform of AT.
Although perturbation of the hinge region might be expected, the
effect seems to have propagated to the heparin binding region.
To determine which conformational changes are significant, and
which reflect the flexible nature of the molecule, the structure
of the  -glycoform compared with
the -form is shown in b.
The color scheme reflects the RMSD from light gray to red for
0-3 Å. The distance between Lys-220 and -139 C is shown
as a dashed green line, and is increases from 5.1 to 7.8 Å
in response to the E381A mutation.
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