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Figure 5.
Figure 5. A Model for the Activated TRAF–Receptor
ComplexThe atomic coordinates for the complex between a TNF-like
ligand and a TNFR were taken from PDB entry 1tnr and are shown
as thin worms (green, light blue, and darker blue) for the
ligand and thick worms (pink, orange, and blue) for the
receptor. The TRAF domain structure from the CD40 complex is
shown as ribbon traces, with the β strands in green, cyan, and
dark blue for each of the protomers of the trimer. The receptor
peptides (pink, orange, and blue) are shown as the CD40 peptide
with an extended amino terminus from the CD30 peptide. Dotted
lines are used to connect the extracellular and the
intracellular portions of the receptor. The amino-terminal RING
and zinc finger domains of the TRAF trimer are shown as green
ovals. Cell membrane is represented in yellow.
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