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Figure 5.
Figure 5. A Comparison of the FKBP12–FK506 and FKBP12–T
β R-I ComplexesA surface representation of FKBP12 bound to
FK506 is shown to the left ([57]). To the right is shown a
surface representation of FKBP12 bound to the T β R-I GS
region. Leu-195 and Leu-196 are bound in the same hydrophobic
pocket used to engage immunosuppressant.
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