Figure 4.
Figure 4: Cs^+-binding sites. a, Stereo image of the electron
density peaks (3.5 )
from anomalous difference Fourier maps calculated using
diffraction data measured from crystals soaked in CsCl. b, Key
interactions between Cs^+ ions at sites 1 and 2 with the
main-chain and side-chain oxygen atoms of Gly 432 and Asp 433,
respectively. c, Stick representation of ASIC1mfc interaction
with Cs^+ at site 2. d, Trigonal antiprism coordination of the
Cs^+ ion by the Gly 432 carbonyl and Asp 433 carboxyl oxygens.
Oxygen atoms (red spheres) form the vertices, whereas solid
lines represent the sides of each of the two staggered triangles
of the antiprism.
)
from anomalous difference Fourier maps calculated using
diffraction data measured from crystals soaked in CsCl. b, Key
interactions between Cs^+ ions at sites 1 and 2 with the
main-chain and side-chain oxygen atoms of Gly 432 and Asp 433,
respectively. c, Stick representation of ASIC1mfc interaction
with Cs^+ at site 2. d, Trigonal antiprism coordination of the
Cs^+ ion by the Gly 432 carbonyl and Asp 433 carboxyl oxygens.
Oxygen atoms (red spheres) form the vertices, whereas solid
lines represent the sides of each of the two staggered triangles
of the antiprism.