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Figure 4.
Figure 4: Proposed lateral diffusion model for the uptake of
hydrophobic substrates by FadL proteins. a, Substrate (red
hexagon) capture from the extracellular medium by a low-affinity
binding site (L)^15; b, diffusion of the substrate into an
adjacent high-affinity binding site H (blue)^15; c, spontaneous
conformational changes in the N terminus (purple) result in
substrate release and create a continuous passageway to the
barrel wall opening formed by the kink in strand S3. The
substrate diffuses laterally through the opening into the outer
membrane (OM). The polar part of the LPS, constituting the
principal barrier in the transport process, is shown in grey.
The extracellular milieu (E) is at the top and the periplasm (P)
is at the bottom.
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