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Figure 4.
Figure 4: Model of the ZP-N domain repeat region of ZP2. a,
b, Domain architecture of ZP2 (a) and three-dimensional surface
model of its ZP-N1–N4 region (b), with relevant features
indicated (see Supplementary Table 5). aa, amino acids.
Glycosylation and positively selected sites are dark blue and
violet, respectively. Unless otherwise specified, the residue
numbers refer to mouse ZP2 sequence. mAb, monoclonal antibody.
c, Detail of the region boxed in b, highlighting a further
disulphide bond between non-canonical Cys residues of ZP-N3. d,
View of the region circled in b, suggesting that
post-fertilization cleavage of ZP-N2 BC loop could affect the
position of ZP-N1 relative to the rest of ZP2.
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