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Figure 4.
Open and closed conformations of NAGK drawn as α-carbon
traces. Shown are the open (A) and closed (B) conformations of
A. thaliana NAGK and the open conformation of T. maritima NAGK
bound to arginine (C) (21). ADP and N-acetylglutamate (NAG) are
drawn in stick representation. The N-terminal domain (N-term;
residues 15-211) is colored blue, and the C-terminal domain
(C-term; residues 212-297) is colored red. The black dot marks
the position of the rotational axis that is normal to the plane
of the page. Rotating the N-terminal domain of the open form of
NAGK by 11° about this axis in the direction indicated by
the arrow in A would result in the closed conformation shown in
B. The right panels show a “top” view similar to that used
in Fig. 2A. This view is perpendicular to the rotational axis,
which is drawn as a light gray arrow.
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