Figure 4.
Fig. 4. Proposed reaction mechanism of PcyA. (a) Close-up
view of BV. Omit electron density map for BV (contoured at 2.5
)
is superimposed on the stick model. The distances between the
carboxyl group of Asp-105 in minor conformation and the lactam
oxygen and nitrogen atoms of D-ring are 3.67 and 2.95 Å,
respectively. (b) Proposed reaction mechanism catalyzed by PcyA.
Reduction schemes at the D-ring (Upper) and at the A-ring
(Lower) are shown.
)
is superimposed on the stick model. The distances between the
carboxyl group of Asp-105 in minor conformation and the lactam
oxygen and nitrogen atoms of D-ring are 3.67 and 2.95 Å,
respectively. (b) Proposed reaction mechanism catalyzed by PcyA.
Reduction schemes at the D-ring (Upper) and at the A-ring
(Lower) are shown.