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Figure 4.
Fig. 4. Superposition of H3 loops at different stages of
ligand complexation. Shown are CDR loops and side chains for
Ab^2 (gray), Ab^2·anthrone (green), and
Ab^3·alizarin red (yellow). Although the Ab^2 and
Ab^2·anthrone structures vary only slightly (Movie 1),
the formation of the final high-affinity complex
(Ab^3·alizarin red) is accompanied by significant
conformational change, in particular of the H3 loop (Movie 3).
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