Figure 4.
FIG. 4. A, binding of Gleevec to Syk. Ligand difference
electron density (2 F[observed]-F[calculated]) contoured at 1
.
B, binding of Gleevec and staurosporine to Syk. Gleevec (yellow)
binding to Syk in the compact cis-conformation mimics the
structure and binding mode of staurosporine (salmon). The key
residues are labeled, and hydrogen bonds are denoted with dashed
lines. The images were prepared with Xfit (25).
.
B, binding of Gleevec and staurosporine to Syk. Gleevec (yellow)
binding to Syk in the compact cis-conformation mimics the
structure and binding mode of staurosporine (salmon). The key
residues are labeled, and hydrogen bonds are denoted with dashed
lines. The images were prepared with Xfit (25).