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Figure 4.
Figure 4. The Conformation of pCDK2 in the pCDK2/KAPt
Complex Represents the Activated ConformationA structural
comparison of CDK2 as the nonphosphorylated monomer in the
pCDK2/cyclin A complex and in the pCDK2/KAPt complex. Except for
differences in the conformation of the activation segment
residues 152–165, the conformation of CDK2 in the pCDK2/cyclin
A binary complex is most similar to the pCDK2/KAPt structure.
The N- and C-terminal lobes of CDK2 are colored white and gold,
respectively, and the C helix is shown in magenta. The
activation segment is green, except for residues 153–164 that
are disordered in monomeric pCDK2 and are shown in red
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