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Figure 4.
Figure 4. Active Site of Boar b-Acrosin(a) The boar
b-acrosin heavy chain carboxyl terminus inserts into the active
site of a neighboring molecule. The figure shows the placement
of the heavy chain carboxyl terminus (residues Pro-255, Pro-256,
and Arg-257) and adjacent loop residues Asp-201, Arg-202, and
Ala-203 within the active site of another molecule (shown as a
molecular surface). The location of the catalytic site serine
(Ser-195) is marked by the pink surface, the p-aminobenzamidine
inhibitor is shown in green, and the specificity pockets are
labeled according to the convention of [24].(b) Corresponding
electron density (2|F[obs]| - |F[calc]| coefficients contoured
at 1 s) for the active site region shown in part (a). Density
for the residues inserted into the active site are shown, along
with the density corresponding to the active site serine
(Ser-195) and the p-aminobenzamidine inhibitor
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