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Figure 3.
FIGURE 3. Nucleotide-induced domain closure in mjAK. A, an
overlay of the ternary complex (yellow ribbons) on the binary
complex (blue ribbons) shows that binding of the ATP analog
AMP-PNP induces a 12.5° rotation around the hinge bending
region (green) of the regulatory domain (light blue) toward the
kinase domain (dark blue). B, an expansion of the active site
showing the movement of latch loop I into position to form
binding interactions with the ribose ring of AMP-PNP and the
closing of latch loop II to complete the hydrophobic pocket of
adenine ring binding.
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