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Figure 3.
FIGURE 3. Crystal structures revealed different dimer
interfaces for  I O18/O8 (a) and AL-09
(b). c, superposition of I O18/O8 (blue and
cyan) and AL-09 (brown and salmon) dimers illustrated that AL-09
had a 90° rotation from the canonical (germline-like)
interface. d, arrangement of key interface residues was
significantly disrupted upon superposition of I O18/O8
(blue) and AL-09 (brown) monomers. The presence of the second
monomers for I O18/O8 (cyan) and
AL-09 (salmon) showed that a canonical dimer interface in AL-09
was sterically impossible, given the conformation of F98 (yellow
highlight). e, stereo images of I O18/O8 2F[o]-F[c]
electron density (at 1  contouring). The images
show the electron density around Trp-35.
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