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Figure 3.
FIGURE 3. Comparison of surface electrostatic charge at the
IL-15·IL-15R  and IL-2·IL-2R
interfaces. A,
IL-15·IL-15R and B,
IL-2·IL-2R complexes are shown as
molecular surface representations in an open book view. Selected
residues are labeled. Electrostatic potentials are mapped onto
the molecular surfaces, with negative potential colored red and
positive potential colored blue. Sites 1 and 2 of the
IL-15·IL-15R complex and patches 1
and 2 of IL-2·IL-2R complex are indicated
with a dashed cyan line and labeled. Note the presence of a
negatively charged groove on IL-15 into which the three knobs of
positive potential (Arg-25, Arg-27, and Arg-36) insert. The
electrostatic potentials were calculated, and the figure was
prepared using the program CCP4mg (38).
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