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Figure 3.
Figure 3. Stereo view of the pentamer-pentamer interface and
the electrostatic potential at the molecular surface. (A) Stereo
view of the pentamer-pentamer interface in human NPM-core
(between monomers A and F). Black dotted lines denote hydrogen
bonds. Highly similar interactions are repeated five times in a
decamer. (B) Pentamer-pentamer interface of Xenopus NO38-core.
Black dotted lines denote hydrogen bonds, while a red ball
represents a water molecule. (C) Pentamer-pentamer interface of
Xenopus nucleoplasmin (Np)-core. Black dotted lines denote
hydrogen bonds, while red balls represent water molecules. (D)
Stereo view of the region around the ARF binding loop (residues
100-117).[31] AKDE loop, GSGP loop, and the cluster of
hydrophobic core-forming residues are represented by pink, light
blue, and cyan colors, respectively. (E) The electrostatic
potential at the molecular surface of human NPM-core, Xenopus
NO38-core, and Xenopus nucleoplasmin-core. The views are down
the twofold axis.
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