Figure 3.
Figure 3 Surface representation of the 20
Å deep funnel leading to the catalytic site. Blue,
side-chain nitrogens of Arg and Lys residues; red, side-chain
oxygens of Asp and Glu; green, side-chain carbons of Tyr and Phe
residues. Yellow, Zn^2+ ions; inhibitors shown as stick models.
(A) Complex with GPI-18431; (B) complex with phosphate. Note the
difference in the shape of the pocket because of withdrawal of
the 'glutarate sensor' (Y700) in the phosphate complex.
20
Å deep funnel leading to the catalytic site. Blue,
side-chain nitrogens of Arg and Lys residues; red, side-chain
oxygens of Asp and Glu; green, side-chain carbons of Tyr and Phe
residues. Yellow, Zn^2+ ions; inhibitors shown as stick models.
(A) Complex with GPI-18431; (B) complex with phosphate. Note the
difference in the shape of the pocket because of withdrawal of
the 'glutarate sensor' (Y700) in the phosphate complex.