|
Figure 3.
Figure 3. Architecture and assembly of the hexadecameric
nsp7–nsp8 complex. (a) The interaction sites between nsp7
and nsp8I/II. Green, nsp7; blue, nsp8. (b) T1 and T2
heterotetramer formation. The two dimers from one tetramer are
illustrated by the surface representation and ribbon diagram,
respectively. Residues: green, polar; yellow, hydrophobic; red,
acidic; blue, basic. Ribbons: green, nsp7; blue, nsp8I; orange,
nsp8II. (c) Possible pathway for assembly of the complex by
heterotetramers T1 and T2. (d) Hexadecameric supercomplex
construction with 'bricks' of nsp8 and 'mortar' of nsp7. The
angle between nsp8I and nsp8II is labeled in magenta. In c and
d, nsp7 molecules interacting with nsp8I and nsp8II are colored
yellow-green and blue-green, respectively.
|
