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Figure 3.
Fig. 3. Coevolving networks of the barrel and plug and the
signaling domain link distant functional sites within FecA. (A)
Ribbon diagrams of the unliganded (yellow) and liganded (blue)
conformations of FecA. Residues T138, R365, R380, R438, and Q570
form the ferric citrate binding site (red sticks) and are each
located within 3.5 Å of the ferric citrate molecule
(magenta CPK model). The SCA-derived network of the barrel and
plug has been mapped onto the structure with the van der Waals
surfaces associated with these residues colored blue. The
locations of those point mutations described in Table 1 are
shown in red. (B–D) Serial sections through FecA as viewed
from the solvent. (E and F) Ribbon diagrams of the signaling
domain of FecA (silver). The SCA-derived network of the
signaling domain has been mapped onto the structure with the van
der Waals surfaces associated with these residues colored blue.
The locations of those point mutations described in Table 1 are
shown in red.
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