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Figure 3.
Figure 3. Comparison of LIS1/PAF-AH and G[αβγ](A) Ribbon
diagram of the G[αβγ] trimer based on PDB coordinates 1GP2
(Wall et al., 1995). G[α] is yellow and is subdivided in the
Ras-like domain (light yellow) and in the helical domain (dark
yellow). G[β] is cyan and G[γ] is green. The G[α]-G[βγ]
interaction involves the N-terminal helix and the switch I and
switch II regions of G[α] (red). The G[β] subunit uses the top
surface of the β propeller, where the outer βD strand connects
to the inner βA strand of the next blade to bind G[α]. The
top surface is preferentially used for ligand recognition by
propeller-like structures (Smith et al., 1999).(B) A LIS1/PAF-AH
hemitetramer is shown. The α[2] subunit has the same
orientation of the G[α] subunit shown in (A). The orientation
of the β subunits is unrelated, although also in this case the
top surface of the propeller is used for binding.
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