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Figure 3.
Figure 3. Comparison of the crystal structure of the
globular domain of the ARQ allele of sheep PrP (blue) and the
NMR structure of human PrP (yellow: 1hjm.pdb): least-squares
superimposition of common residues, with an rms DIFFERENCE=1.73
Å for 100 C^a atoms. In addition to the three helices, the
intramolecular b-sheet (arrows, b1:129-131; b2:161-163) is shown
in red for sheep PrP, and grey for human PrP. The YYR epitope is
at 162-164. The loop 164-174 between b2 and H2, is shown in
green for sheep PrP. The three polymorphic residues of sheep
(A133,R151,Q168), are shown in magenta (Figure drawn with Spock).
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