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Figure 3.
Figure 3. Structures of the Active Site in Complex with
Ligands(A), (B), (C), and (E) are shown in stereo. Potential
hydrogen bonding interactions are shown by dashed lines, waters
as red spheres.(A) The Ecm1-AdoMet complex.(B) The Ecm1-AdoHcy
complex.(C) The Ecm1-cap complex.(D) 2.5 Å simulated
annealing map contoured at 1.0σ covering the cap guanylate
ligand.(E) The Ecm1-AdoHcy-cap complex.(F) 2.4 Å F[o] −
F[c] map contoured at 1.5σ covering the cap guanylate and
AdoHcy ligands.
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