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Figure 3.
Fig. 3. Structural comparisons of the environment around HA2
Trp21 in 18HA0 and H5 HA1/HA2. The avian H5 structure (PDB ID
code: 1jsm [PDB]
) was aligned with the 18HA0 model for comparison, as in Fig. 2.
In the avian structure (A), HisA18 and HisA38 are  3.7
Å apart, whereas in 18HA0 (B), the same residues are 13.5
Å apart. The TrpB21 "flip" in 18HA0 is stabilized by close
proximity to the side chains of TrpB14 and Ala^B36. This figure
was generated in the same way as Fig. 1A.
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