|
Figure 3.
Figure 3. Stereo representations of the hapten interactions
in the antigen-binding pocket. (a) Hydrogen bonds are shown as
broken green lines. Arg^H100 forms an apparent cation-π
sandwich with Tyr^L32 and the phenyl ring in the hapten[21], and
prevents further interactions of the hapten with CDR L1 or L2.
(b) The side view of the binding pocket shows that the majority
of the side-chain interactions are derived from the heavy chain.
His^H58 stacks against the second phenyl ring in the substrate.
Leu^L96 has been omitted from this view for clarity.
|
