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Figure 3.
Figure 3. Putative Ligand Binding Sites of X2IRBP(A) Ribbon
stereo diagram of X2IRBP (shown in yellow) superposed with
2-enoyl-CoA hydratase (blue) in complex with octanoyl-CoA (red).
The bound ligand of 2-enoyl-CoA hydratase was transferred from
the 2-enoyl-CoA hydratase/octanoyl-CoA structure to the
equivalent position in X2IRBP. The fatty acid portion of the
ligand binds to the hydrophobic site 1, as identified in Figure
3b.(B) Hydrophobicity surface representation, where white
represents high hydrophobicity and blue high hydrophilicity. The
arrowhead identifies a shallow hydrophobic binding cleft between
domains A and B, the putative first binding site (site 1). The
arrow identifies a cavity located in a hydrophobic patch that
leads to the potential second binding site (site 2).
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