Figure 3 - full size

Figure 3.
Figure 3. Loop ordering on NO binding. Space filling views of the distal pockets in the NP4 -NO (left) and NP4 -CN- (right) structures. The view is from above the distal pocket, with heme shown in black, heme oxygens in orange, NO in magenta, CN- in cyan, five water molecules in red, and loops A-B and G-H in green. Binding of NO leads to reordering of the A-B and G-H loops, expulsion of the water molecules, burying of NO and Asp 30, and packing of Leu 130 against the NO molecule.