Figure 3 - full size

Figure 3. Figure 3. Superposition of the structures of the native enzyme (cyan) and the FKBP-FK506 complex (yellow). (a) Global view; (b) close-up view. The interatomic distances of the native enzyme are displayed in orange. Distances in the FK506 complex are in light blue. The active site cleft accommodates the structure of the inhibitor FK506 and is wider but shorter in the FK506 complex compared to the native enzyme.