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Figure 3.
Figure 3. a,b, Molecular surface and worm representations of the
SAM homodimer. The molecular surface of one subunit is shown
with hydrophobic (Met, Val, Leu, Ile, Phe,), basic (Arg, Lys)
and acidic (Glu, Asp) side chains colored green, blue and red,
respectively. The two perspectives differ by a 90° rotation
about the vertical axis. In (b) the two−fold rotation axis
relating the two subunits of the dimer is shown. The buried
surface area of the dimer interface is 1,923 Å^2. All
molecular surfaces were generated using GRASP^1. c, Electron
density in a simulated annealing^32 omit map computed at 2.0
Å and contoured at 1.5  .
|2F[o] − F[c]| coefficients were used to calculate the map.
Superimposed are the omitted residues Asp 918, Trp 919 and Leu
920 of the final EphA4 model.
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