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Figure 3.
Figure 3. Relationship between the Cofilin and Gelsolin
Families(A) Superposition of the mean structures of destrin
(black) and three members of the gelsolin family (red, gelsolin
segment-1; green, villin segment-1; blue, severin segment-2). We
used coordinates provided by [44], Model 1 in Protein Data Bank
entry 1VIL ( [40]), and Protein Data Bank entry 1SVR ( [61]),
respectively. The regions used for superposition are described
in the text and also shown here in bold lines. Start and end
residues of the regions are numbered.(B) Sequence alignments of
destrin and gelsolin family members whose tertiary structures
have been solved. Meaningful residues are colored (green,
hydrophobic; red, acidic; blue, basic). Regular secondary
structure elements are underlined and boxed by colors (yellow,
α helix; light blue, β strand). The sequences of destrin and
gelsolin segment-1 are numbered, and numbering of the latter is
adjusted to the plasma-form corresponding to [44]. Regions used
for the superposition in (A) are represented by dotted lines.
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