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Figure 3.
Figure 3. Stereo diagrams [41 and 42] of SIGMAA weighted
2F[o]-F[c] maps from round 13 of the refinement. The structure
was refined with either (a) a farnesyl (in green) in the pocket
(map contoured at 1s) or (b) the water structure (red spheres)
from Gaudet et al. [12] (PDB code 2TRC; contoured at 0.8s). The
refinement was carried out with the program X-PLOR [33], and
included a bulk solvent correction as well as conventional
positional refinement. Note that in (b) the waters have moved
very little from their starting positions and make good hydrogen
bonds with surrounding residues. Only hydrogen bonds between
protein residues are shown (dashed lines).
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