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Figure 2.
(a) Interactions of active site zinc with inh1 and inh2. BoNT
F residues in the BoNT F–inh1 and BoNT F–inh2 complexes,
D-Cys and D-Cys-sulfinic acid, are shown in cyan, light gray,
orange and green stick model, respectively. Whereas the sulfur
of D-Cys in inh1 has one interaction (2.52 Å with zinc,
red label), sulfur, OD1 and OD2 of D-Cys sulfinic acid in inh2
have many interactions with the enzyme molecule (blue labels).
(b) Interactions of inh1 at and near the BoNT F active site.
BoNT F is shown in ribbons (sky blue) and stick model (light
gray) and zinc is in sphere model (magenta), whereas inh1 is in
green stick model. BoNT F and VAMP residues are labeled in black
and blue, respectively. All interactions between BoNT F and VAMP
are shown using dashed lines.
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