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Figure 2.
Figure 2. Binding Position of Thio and Nosi on the 50S
Subunit
(A) Overview of thiopeptide binding site on the D.
radiodurans 50S subunit. Interface view of the 50S subunit (rRNA
and r-proteins colored light and dark blue, respectively) with
the thiopeptide binding site boxed. Enlargement of boxed region
reveals that the thiopeptides Thio (cyan) and Nosi (green) bind
within a cleft between the N-terminal domain (NTD) of r-protein
L11 (yellow) and the 23S rRNA H43 and H44 (orange).
(B and
C) 2mF[o] − DF[c] σ[A]-weighted difference electron density
maps (meshed) contoured to 2σ with (B) Thio, (C) Nosi, L11-NTD,
and H44 colored as in (A).
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