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Figure 2.
Structure of the N234G mutant (stereo). A, structural
superimposition and comparison of the nucleotide binding
interface of the N234G mutant (green) and WT:AMPcPP (yellow)
structures. Only structural features in the vicinity of the
nucleotide-binding site, the P loop, and the L2 loop/α6 helix
are highlighted. In addition, the mutated residue, Asn/Gly-234
is shown in a ball-and stick model representation. B, structures
of the WT protein with AMPcPP (yellow) and ADP (blue) bound,
respectively, are shown for reference in the same orientation as
shown in A. Superposition of coordinates was conducted using SHP
(53).
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