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Figure 2.
Overview of RECQ1 structure. (A) Ribbon representation of a
single RECQ1 molecule, viewed from 3 perpendicular orientations.
The subdomains are identified by color: Core helicase domain D1,
red; core helicase domain D2, blue; zinc motif (ZnD), yellow;
helical hairpin (HH), orange; WH domain, green; and the
β-hairpin in purple. ADP is shown in space-filling form. (B) E.
coli RecQ, colored as in A. [PDB ID code 1OYY (30)] The molecule
is viewed in the same orientation as the central view in A,
using the D2 domain as a reference. (C) Side-by-side comparison
of bacterial RecQ (Left) and human RECQ1 (Right). Arrows
indicate the rotations of the various domains. The WH domain
rotates 90° around the vertical (compare orientation of
helix α1 marked by asterisk), the HH tilts up by 10°, and
the D1 rotates away from D2.
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