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Figure 2.
Figure 2: Molecular surfaces of group-1 and group-2
neuraminidases with bound oseltamivir showing the 150-cavity in
the group-1 structure that arises because of the distinct
conformation of the 150-loop. a, b, N1 (a; green) and N9 (b;
yellow) shown in surface representation with the protein main
chain shown in 'worm' representation. c, Superposition of the
active sites of apo-N1 (green) and N1 complexed with oseltamivir
(blue). Part of the electron density map from a low-resolution
(5.5 Å) difference Fourier calculated between apo-N1 and
oseltamivir-bound N1 data sets is shown in blue to indicate the
position of the 150-cavity.
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