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Figure 2.
Figure 2. Substrate Recognition in the a Subunit
(A)
Local structures around the adenine base binding site in the a
subunit, observed in forms I (red) and V (orange, green). The
bound ligand is acetyl-CoA, which is an analog of
3-hydroxyacyl-CoA.
(B and C) The corresponding structures
of the (B) proximal and (C) distal subunits in form II.
(D)
Superimposition of the two a subunits in the apparently
symmetric form I, in which the acetyl-CoA (the red space-filling
model) was observed. The ligand bound subunit (red) is more open
than the unliganded one (blue). As a consequence, only the aC
domain exhibits a significant difference. The circle with the
broken line indicates the adenine base moiety in (A).
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