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Figure 2.
Figure 2. Architecture of arginine-sensitive NAGK. The
TmNAGK ((a) and (b)) or PaNAGK ((e) and (f)) hexamers are viewed
((a) and (e)) along or ((b) and (f)) perpendicularly to the
molecular 3-fold axis. Each homodimer is coloured differently.
In (a) and (b) arginine, and in (e) and (f) MgADP and NAG are
represented in space-filling representation and coloured. In (a)
and (e) the arrowpoints indicate the interlaced N helices at one
junction. (c) TmNAGK and (d) EcNAGK26 homodimers, viewed along
their 2-fold axes. The N and C lobes are in blue and green,
respectively, and the N helix is in red. In (c) arginine is
shown in space-filling representation, and coloured. The ligands
shown in (d) are in ball and stick representation, and are NAG
and AMPPNP.
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