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Figure 2.
Figure 2. The chemical structures of three PTR1 inhibitors:
methotrexate, CB3717 and trimethoprim. The molecules are
depicted in a similar orientation in all Figures. The
methotrexate molecule is depicted with the pterin-ring flipped
about the N2-N5 axis relative to other pterins as actually
observed in the PTR1 active site.
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