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Figure 2.
Figure 2. Carbohydrate-binding and calcium-binding sites.
(a) C^a traces of the DC-SIGNR R8 (blue) and DC-SIGNR CRD (gray)
primary calcium-binding sites showing side-chains involved in
coordinating calcium. In the absence of carbohydrate, Asp377 is
not involved in calcium coordination. The calcium ion, seen in
nearly the same position in both structures is shown in yellow
(Ca2). A water molecule (red) is present in the location where
normally ligand binds (DC-SIGNR R8 structure). (b) The secondary
calcium-binding site shows the C^a loop in DCSIGNR R8 and
DC-SIGNR CRD Loop movement is observed between ligand-bound and
apo structures from closed to open, respectively. Calcium ions
present in the structure of DC-SIGNR CRD only are shown in gray
(Ca1 and Ca3). Side-chain movements between each structure are
summarized in Table 2.
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