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Figure 2.
FIG. 2. Stereo view of alternate Gleevec binding modes.
Gleevec bound to unphosphorylated Abl (green) adopts an
extended, trans-confirmation, which is incompatible with the
phosphorylated/more active confirmation of Abl (blue). Gleevec
binds to the unphosphorylated/active confirmation of Syk
(yellow) in a very different cis-conformation, which is more
compatible with binding to the phosphorylated/more active
conformation of Abl (blue). The key residues are labeled.
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