|
Figure 2.
Figure 2: Steric exclusion of water results in protection of
peptidyl-tRNA from deacylation in the uninduced state. When
the peptidyl transferase centre is not in the induced state, as
occurs when ChPmn and CCApcb (green) are bound, the ribosome
(orange surface) occludes water from positions that could attack
the ester group. Theoretical water molecules (red spheres), are
shown aligned for attack at 105° to the plane of the ester
group, 2.8 Å away from the ester carbon. Steric clashes with
A2486(2451) and C2104(2063) block the position on one side,
whereas the uninduced conformation of U2620(2585) would block
the other side.
|
