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Figure 2.
Figure 2. A: Ribbon diagram of a superposition of 18204011
(mouse) and quinone oxidoreductase from E. coli (PDB: 1qor)
grey. The structures were superimposed on their
nucleotide-binding domains. The NADPH molecule bound to quinone
oxidoreductase is shown in cpk mode. B: Close up view of the
active site. The NADPH molecule and the sulfate bound to the
active site of quinone oxidoreductase are shown in ball and
stick. The active site tyrosine (Y52) as observed in quinone
oxidoreductase from E. coli and its potential counterpart (Y64)
in 18204011 (the Y64 side-chain has been modeled here due to
disorder in the crystal structure) are shown in ball and stick.
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