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Figure 2.
FIG. 2. Structural comparison of HNTX-IV and correlated
toxin molecules. A, ensembles of 20 energy-refined conformers
representing the solution structures of native HNTX-IV, K27A,
and R29A. The backbones are shown in cyan, green, and gray,
respectively. Positively charged side chains are shown in blue,
and negatively charged side chains are shown in red. B,
comparison of HNTX-IV to conotoxin GS (CTX-GS) and
µ-conotoxin GIIIA (CTX-GIIIA) (conotoxin GS, Protein Data
Bank code 1AG7 [PDB]
; µ-conotoxin GIIIA, Protein Data Bank code 1TCG [PDB]
). The  -sheet is shown in
yellow, the turn is shown in blue, and the random coil structure
is shown in green. Three disulfide bonds of each molecule are
indicated. The letters N and C refer to the amino and carboxyl
termini, respectively.
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