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Figure 2.
FIG. 2. Overall structure of dok1 PTB domain. a, ribbon
stereo diagram showing the fold of the Dok1 PTB domain (green)
and the orientation of the bound RET phosphopeptide (white). The
ribbon diagram was generated with the program BOBSCRIPT (11). b,
structure-based sequence alignments of the nine Doks and hIRS1
PTB domains. Sequences of mouse Dok1-(147-264), human
dok1-(147-264), mouse Dok2-(144-259), human Dok2-(141-257),
mouse Dok3-(156-266), mouse Dok4-(133-242), human
Dok4-(133-242), mouse Dok5-(134-242), human Dok5-(129-232), and
human IRS1-(160-262) were aligned. Numbers refer to mouse Dok1.
The conserving residues were boxed in red and blue. Critical
arginines for phosphotyrosine recognition are indicated by green
dots. Alignment was generated using CLUSTAL X (1.8).
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